ROLLED PCL MESHES AS BIOCOMPATIBLE SCAFFOLDS FOR LIGAMENT REPAIR

Hagar Kenawy Department of Chemical and Biomolecular Engineering, Lafayette College Easton, PA 18040 Dr. Aaron Goldstein Department of Chemical Engineering, Virginia Tech Blacksburg, VA 24061

Treatments for anterior cruciate ligament (ACL) injuries currently include the use of metal screws, autografts, and allografts. Unfortunately, such treatments have side effects such as low biocompatibility, donor site morbidity, and limited availability. Electrospinning can be used to fabricate strong, biocompatible fibers that are resilient and provide topographic features to guide cell adhesion and orientation. However, electrospun meshes have small pores that inhibit cells from proliferating and a shape that is not amenable for formation of 3D tissues. Therefore, we propose that 3D cylindrical composites can be made by combining electrospun fiber meshes with collagen and rolling the composite into a cylindrical shape. To this end, rolled polycaprolactone (PCL) fibers were created which varied in the angle of fiber alignment, the collagen concentration, and the fiber surface chemistry. Monotonic tensile testing was conducted to measure the effect of fabrication conditions on the composites’ mechanical properties. This study confirms that fiber orientation, collagen concentration, and chitosan coated fibers vary the mechanical properties of the resultant cylindrical PCL meshes. Our next step is to examine how these properties affect cell adhesion, proliferation, and infiltration into the rolled composites.


Additional Abstract Information

Presenter: Hagar Kenawy

Institution: Lafayette College

Type: Poster

Subject: Biomedical Engineering

Status: Approved


Time and Location

Session: Poster 7
Date/Time: Fri 1:20pm-2:20pm
Location: University Center Ballroom - Tripod 15 Side A